April 25, 2008

The history and psychology of wine:

The May issue of The Psychologist has a freely available cover article on wine which takes a suitably meandering route through the history and psychology of the fermented grape.

It's full of fascinating facts from times past mixed in with recent findings from research studies.

I particularly liked this section, which starts with an ancient Persian decision-making technique (still widely used during weekends in London) and goes on to look at the influence of music on wine purchasing:

Many psychoactive substances have been associated with creativity, and ancient Persians are reported to have used wine to facilitate decision making. An issue would be explored whilst intoxicated and, the next day, the conclusions that stood up to sober scrutiny were adopted.

Some psychologists have demonstrated associations between music played in retail outlets and subsequent wine purchases. Playing classical or pop music does not influence the amount of wine purchased but appears to influence the average price of bottles selected, with classical music leading to sales of more expensive wines (Areni & Kim, 1993). It also appears that playing French or German music influences selections, with more purchases of wines from the same origin as the music (North et al., 1999).

There's also plenty more ammunition in the article for anyone wanting to convince themselves that wine snobbery is bunk. For example, adding red food colouring to white wine is enough to convince wine masters that they can 'nose' red wine scents.

Unfortunately, the article on the webpage is almost impossible to read because of the broken formatting, so I suggest just reading it straight from the pdf.

Link to article 'On vines and minds'.
pdf of same.

Full disclosure: I'm an unpaid associate editor of The Psychologist but am ignorant about wine!

—Vaughan.

March 24, 2008

Common scents and the psychology of smell:

Nerve has a brief but interesting interview with psychologist Rachel Herz who talks about her research on the sense of smell and how it can influence our mind and behaviour.

I've not encountered Herz's work before but it turns out she's done a great deal of scientific research on the psychology and neuroscience of smell and has just written a book, The Scent of Desire, which seems to present the science of smell in an accessible format.

The interview contains a number of gems, but this particularly caught my eye:

Why do we grow accustomed to odors, but not to something like sound? In other words, why is the stench of garbage outside my apartment nowhere near as distracting as the drilling?

When we experience olfactory adaptation, the receptor literally stops responding to a chemical in the air after about twenty minutes. We adapt to all the sensations that are out there, but when the drilling starts and stops, your attention focuses on it and you're irritated.

Smell is a fascinating area, perhaps because it is relatively unstudied (especially compared to vision).

We previously covered an interesting review article that talked about the fact that the brain has two smell networks - something that came us a complete surprise to me.

Link to Nerve interview with Rachel Herz.
Link to more info on The Scent of Desire book.

—Vaughan.

March 16, 2008

Pica: put your money where your mouth is:

An upcoming article in the medical journal Clinical Toxicology reports on a man who suffered lead poisoning owing to his habit of eating roofing plates.

The tendency to eat the inedible is known as 'pica'. It is an established psychiatric diagnosis, is well-reported in the medical literature and has given us some of the more unusual case reports of recent years.

Although there is a specific diagnosis, the term is also used more widely as a general label for any eating behaviour that focuses on inedible objects.

Two of the most striking cases have involved coins. The x-ray on the right is from a case report from the New England Journal of Medicine where doctors discovered five and a half kilograms of coins, necklaces, and needles in a patient's stomach.

In another case report from 1998, a British patient had swallowed £175.32 pounds worth of loose change and had a history of eating a wide range of curious objects:

At different times she has eaten tablets, coins, nuts, wire, plastic, 'purple hearts', Bob Martin's dog conditioning powder and dried flowers. There is much comment made throughout her medical notes detailing vigorous negotiations about the colour, size, number, timing and supply of medication, including a large batch of hand-written letters to her doctor.

The behaviour in the more extreme cases in adults is usually associated with psychosis, as was the case with these two individuals.

It was also the case with one other gentleman, who had suffered lead poisoning after swallowing over 200 live bullets. The case report was rather wittily titled 'Bite the Bullet'.

Normally, however, pica is most commonly seen in children with learning difficulties or autism spectrum diagnoses.

Perhaps giving partial support for the stereotype that pregnancy leads to unusual food cravings, it is known to occur more commonly in pregnant women, particularly from lower income families.

It's not clear why it occurs, but interestingly, it has been linked to iron and zinc deficiencies.

Link to NEJM case report with x-ray.

—Vaughan.

March 03, 2008

Are you experienced? Does it matter?:

Time magazine has an article on the counter-intuitive psychology of expertise and experience. It turns out simple experience might not add anything to our competency, it's how we use our time in attempting to master a skill that counts.

The article notes that research has typically failed to show that experience, on its own, predicts task performance. In other words, old hands often do no better than novices.

Unfortunately for us, it seems the secret to expertise lies within the well-known saying that 'genius is 1% inspiration and 99% perspiration'.

Research suggests that it is experience of practising the most difficult and laborious aspects of a skill that are key.

Ericsson's primary finding is that rather than mere experience or even raw talent, it is dedicated, slogging, generally solitary exertion — repeatedly practicing the most difficult physical tasks for an athlete, repeatedly performing new and highly intricate computations for a mathematician — that leads to first-rate performance. And it should never get easier; if it does, you are coasting, not improving. Ericsson calls this exertion "deliberate practice," by which he means the kind of practice we hate, the kind that leads to failure and hair-pulling and fist-pounding. You like the Tuesday New York Times crossword? You have to tackle the Saturday one to be really good.

Take figure-skating. For the 2003 book Expert Performance in Sports, researchers Janice Deakin and Stephen Cobley observed 24 figure skaters as they practiced. Deakin and Cobley asked the skaters to complete diaries about their practice habits. The researchers found that élite skaters spent 68% of their sessions practicing jumps — one of the riskiest and most demanding parts of figure-skating routines. Skaters in a second tier, who were just as experienced in terms of years, spent only 48% of their time on jumps, and they rested more often. As Deakin and her colleagues write in the Cambridge Handbook, "All skaters spent considerably more time practicing jumps that already existed in their repertoire and less time on jumps they were attempting to learn." In other words, we like to practice what we know, stretching out in the warm bath of familiarity rather than stretching our skills. Those who overcome that tendency are the real high performers.

Link to Time article 'The Science of Experience'.

—Vaughan.

February 29, 2008

Fragments of consciousness:

Dana's online neuroscience magazine Cerebrum has a fantastic article on trauma and dissociation - the splitting of consciousness that apparently makes some aspects of the mind inaccessible to others.

Dissociation is a term that's used rather loosely in modern psychology and psychiatry. It is sometimes used to be synonymous with derealisation or depersonalisation, describing a feeling of being detached from reality or not being 'grounded' in your usual sense of self.

However, in its original and most interesting formulation by the French psychiatrist Pierre Janet, it describes the splitting of consciousness so one part of conscious experience is compartmentalised, becomes inaccessible, is literally 'dis-associated' from the rest.

Its not clear why it occurs, but Janet's theory (often erroneously ascribed to Freud) suggests its a defence against psychological distress. Like the mental equivalent of brushing something under the carpet until you're unaware it existed or you even did the brushing.

Regardless of whether it is genuinely a 'defence' in this sense, it is thought to be at play in conversion disorder, where a person might experience paralysis despite having no damage to the muscles or nervous system (so called 'hysterical paralysis').

There is now growing evidence that the high level control systems in the brain deliberately inhibit the movement in the immobile limb, outside the conscious control of the patient.

It is also thought to be the mechanism by which hypnosis has its effect on those susceptible to it. In this case, however, it is a form voluntary dissociation guided by suggestion - meaning someone can have the experience of, for example, limb movement without the associated sense of having willed the action.

One of the most striking demonstrations of this form of dissociation is where some people can be hypnotised not to be bothered by pain, despite the fact they can report on its intensity - even to the point of surgical operations being possible without anaesthetic in some rare cases.

Perhaps it's not surprising then that dissociative disorders, where patients are seemingly permanently dissociated from their memory (dissociative amnesia) or dissociated from their senses or actions (conversion disorder) are particularly linked to trauma.

The most controversial of these syndromes is what used to be called 'multiple personality disorder', but is now called 'dissociative identity disorder' to suggest that the patient's very personality structure has become dissociated from itself, seemingly leading to several identities or 'alters'.

It's partly controversial because it was so obviously over-diagnosed in a period of 1950s and 60s American psychiatry that was seemingly drunk on Freudian theory without recourse to the strong coffee of scientific testing.

But its also controversial because its so rare despite still being in the diagnostic manuals. For example, I've never met a patient with the condition, and I've never met anyone who's met a patient with the condition, whereas I've seen many patients with dissociative amnesias and conversion disorders.

The Cerebrum opens as if it's about 'multiple personality disorder' but don't be fooled - it's actually a really good review of what cognitive science has told us about how trauma might cause dissociation (almost all the research mentioned is on memory rather than 'multiple personalities').

This is still a controversial area but the article gives the case for the link. The article presents evidence that experience of childhood abuse, both physical and sexual, may be particularly linked to dissociation, perhaps suggesting that it arises from an attempt at a 'defence' in some cases.

Cognitive scientists are now increasingly interested in dissociation and hopefully this new level of interest should unlock some of the its mysterious secrets.

Link to article 'Coming Apart: Trauma and the Fragmentation of the Self'.

—Vaughan.

February 21, 2008

The science of 'voodoo death':

Can you die from a voodoo curse? Physiologist Walter Cannon was better known for his work on emotion but was fascinated by the idea that someone could die from fright - something he nicknamed 'voodoo death'.

He collected anecdotes from around the world of people who had died after being cursed in a now classic 1942 article.

But rather than simply recount the tales as curiosities, he speculated on the medical basis of how someone might die of fright - triggering a whole line of research into neurocardiology, the study of how the brain and heart work together.

Cannon's ideas were recently revisited by physician Esther Sternberg who looked at whether scientific developments since 1942 have made us any the wiser to this intriguing phenomenon.

While there is no clear idea on whether the belief in a curse directly kills many people, it seems Connon's ideas on fear's effect on the body had remarkable foresight and preceded many later discoveries about body-brain connections.

If you're interested in hearing more, psychiatrist Stuart Brown gave one of the prestigious 2006 'TED' talks on play, which is available to view on the National Institute of Play's website.

Link to Cannon's 1942 "Voodoo" Death article.
Link to Sternberg's 2002 update.

—Vaughan.

February 20, 2008

Three impossible things before breakfast:

The Guardian has a insightful piece by journalist Rik Hemsley describing his personal experiences with Alice in Wonderland syndrome, where the 'body image' or 'body map' becomes distorted, leading the affected person to feel like particular parts of the body, or the whole of it, have changed size or shape.

It doesn't usually involve direct visual hallucinations, but can lead to the sensation that the world around you has grown to an enormous size, or that you have shrunk.

It was first described by psychiatrist John Todd in a 1955 article that you can read freely online, which I discovered when writing an previous post on the neurology of Alice in Wonderland.

It's usually associated with epilepsy or migraine although is actually quite common, although not always in such an intense form as The Guardian article describes.

Children often experience it but grow out of it as they reach adulthood (both of which happened to me).

Link to Guardian article 'I have Alice In Wonderland syndrome' (via BB).
Link to full-text of Todd's original article.

—Vaughan.

February 18, 2008

A history of Freudian fiction:

The changing fortunes of psychoanalysis have been reflected in some of the greatest novels of the last hundred years, a literary history recounted in an article for The Guardian.

The piece is by historian Lisa Appignanesi, author of the highly regarded new book Mad, Bad and Sad: A History of Women and the Mind Doctors from 1800.

The article notes that two recent novels (Kureishi's Something to Tell You and Vickers' The Other Side of You) have reversed the recent tradition of portraying psychoanalysts as somehow deviant, unethical or intellectually bankrupt.

The low-point for the creative depiction of Freudian mind doctors was probably Nabakov's novel Lolita, which is presented as a faux psychiatric case study of a paedophile.

You might think that someone who wrote a widely-read novel about a middle-aged man who desired under-aged girls had good reasons to dislike any theory which attempted to uncover unconscious motivations, but Nabakov was famously and venomously anti-Freudian even before he began writing his masterpiece.

He first started knocking psychoanalysis in his second novel, The Defense, and he often referred to Freud as the 'Viennese Quack' and his theories as 'voodooism' for the rest of life his.

This negative portrayal is not universal though, and many novels contain sympathetic and even highly complementary depictions. For example, Appignanesi notes that in Plath's semi-autobiographical novel The Bell Jar, Dr Nolan is "something of a guardian angel amid the horror of asylum life".

Interestingly, the more recent positive portrayals of psychoanalysts mirror some positive results in the scientific literature.

Two recent randomised controlled trials have found that psychoanalytically-inspired treatments can be effective.

A recent trial on treatments for 'personality disorder' found it effective, as did a recent trial on using it as a treatment for panic disorder.

Unfortunately, these are still a drop in the ocean compared to the evidence for some other psychological treatments, but hopefully this is a sign that psychoanalysis is beginning to adopt a more scientific approach to its theories and practice and we'll be better able to separate the wheat from the chaff.

Link to Guardian article on psychoanalysis and literature (thanks Kat!).

—Vaughan.

February 12, 2008

Implicit associations:

You might have prejudices you won't admit to, or, don't even know about. The Implicit Attribution Test claims to measure these hidden associations and it's been one of the most important psychological developments during the last decade.

Edge has a video interview with two of its creators, psychologists Mahzarin Banaji and Anthony Greenwald, and an online version of the IAT which allows you to test your unconscious associations in relation to the US presidential candidates.

The IAT is a computer task that measures the strength of automatic, implicit or unconscious associations between concepts.

Let's say we're interested in whether black or white faces are more linked to positive or negative associations.

Faces of black or white people, and either pleasant or unpleasant words are flashed up on screen, one at a time. Participants are asked to press one key if the face is black or the word is pleasant, and other if the face is white or the word is unpleasant.

In other words, you're asked to classify both black faces and pleasant words using the same response, and white faces and unpleasant words using the same response.

Next, you're asked to do the same thing, but with the reverse associations: so you're asked to classify black faces and unpleasant words together, and white faces and pleasant words together.

The idea is that you're going to be quicker doing whichever classification best matches associations you already have.

So, if you already have unconscious associations between white and pleasant, and black and unpleasant, you're going to be quicker when these two responses are grouped.

Importantly, the idea is that these associations are different from our conscious attitudes. Someone who is definitely not racist might still have negative associations with black people, perhaps because of exposure to social stereotypes.

Most studies have more than just the two conditions, to control for order, practice and other effects and if you're interested, you can take part in this exact experiment online.

It was originally thought that the test could uncover people's implicit or hidden attitudes (indeed, it was originally called the Implicit Attitude Test) but it's now generally thought of just in terms of associations, because, in effect, it measures how closely two things are linked, and implicit attitude sounds more like a sort of evaluation or stance on something.

The value in this sort of test is not only in that it can pick out associations we might have but don't admit to or aren't aware of, but it can also map out how various things influence the unconscious structure of meanings in the mind and brain.

Needless to say, it's been researched intensively since it was first uncovered, with research suggesting it can even pick up on hidden violent associations in psychopathic murderers.

Link to video interview and presidential IAT at Edge.
Link to previous WashPost article on the IAT.

—Vaughan.

February 07, 2008

Psychedelic Science online:

In 1997, BBC science programme Horizon broadcast a legendary edition on the use of psychedelic drugs in medicine. Luckily, it's been uploaded to Google Video and you can now watch the whole thing online.

It came at an interesting time in psychedelic drug research - when the authorities were still touchy (they'd only raided Shulgin's licensed lab three years earlier) but were just starting to allow some stirrings of research since they'd shut it down almost completely in the 1960s.

The programme looks at the history of psychedelic drug research when it was still easily possible, focusing on Osmond and Hoffer's early work on using LSD in treating addiction and facilitating psychotherapy.

It's also got loads of great historical footage from the early research but also talks to the new generation of researchers looking at compounds such as ayahuasca and ibogaine, who are now the senior figures in this growing area.

Unfortunately, the video is a bit grainy in places but it's quite watchable and it's got a great soundtrack. The producers used Future Sound of London, Massive Attack and a number of tracks from the Ninja Tune label to give the programme a trippy feel.

Link to 'Psychedelic Science' edition of Horizon.

—Vaughan.

January 28, 2008

Facing down the competition in business and politics:

The Economist covers an intriguing study that found the financial success of a company can be largely guessed by making a judgement based on photographs of the chief executives.

Most interestingly, the people doing the guessing weren't particularly skilled in business or finance, they were undergraduate student volunteers.

And Dr Ambady and Mr Rule were surprised by just how accurate the students' observations were. The results of their study, which are about to be published in Psychological Science, show that both the students' assessments of the leadership potential of the bosses and their ratings for the traits of competence, dominance and facial maturity were significantly related to a company's profits. Moreover, the researchers discovered that these two connections were independent of each other. When they controlled for the “power” traits, they still found the link between perceived leadership and profit, and when they controlled for leadership they still found the link between profit and power.

These findings suggest that instant judgments by the ignorant (nobody even recognised Warren Buffett) are more accurate than assessments made by well-informed professionals. It looks as if knowing a chief executive disrupts the ability to judge his performance.

Other studies have looked at whether it is possible to judge the success of politicians from their photographs.

Perhaps sadly, it seems it is possible. A study [pdf] published in Evolution and Human Behavior found that face shape could reliably predict voter preference in nine leadership elections from four countries - Australia, New Zealand, the UK, and the USA.

A study just published in the Proceedings of the National Academy of Sciences found that photograph-only judgements of competence could also predict the winners in election for US state governor, even when they were flashed on-screen for less than a quarter of a second.

Interestingly, showing people the faces for longer actually changed people's competency ratings and reduced how well these judgements predicted the election winners.

Link to Economist article 'Face value'.

—Vaughan.

January 27, 2008

Out on a phantom limb:

ABC Radio National's opinion programme Ockham's Razor has an engrossing edition on how our perception and ownership of our body can break down after brain injury - leading to disorders where we think our limbs are someone else's, where we feel there's a phantom body behind us, or where we think we've been cloned.

The talk is by neuropsychologist John Bradshaw who specialises in understanding how the body is represented by the brain, including the experience of having feelings from an amputated phantom limb.

The talk is a little dense in places but more than worth the attention it needs, as the somewhat wordy sentences unpack into an evocative tour through the far reaches of some strikingly neurological syndromes.

One of the most unusual of these disorders is somatoparaphrenia.

While limb paralysis is not unusual after brain injury, in somatoparaphrenia the patient denies the limb is their own and often suggests that it is someone else's, such as their husband's, their doctor's, or even a 'dead' limb that has been attached by people trying to trick them.

One of the earliest discussions of these phenomenon is in a 1955 paper on the personification of paralysed limbs. Rather wonderfully, the full text of the paper is available online.

Link to Ockham's Razor on bodily integration, identity and brain injury.
Link to paper 'Personification of Paralysed Limbs in Hemiplegics'.

—Vaughan.

January 22, 2008

Sensory Processing and Neurotopographics:

While we're on the subject of art and neuroscience I recently discovered a couple of pieces that caught my interest.

The picture is a piece by Sandra Dawson called 'Sensory Processing' which has combined a cap used for EEG recordings of the brain with comforting objects and materials.

I recycled two EEG caps, cut up pyjama bottoms which were freeform crocheted with the leads and black yarn, with iPod headphones
symbolizing synaesthesia with output from the eye going to the ear.

It's called "Sensory Processing" and is meant to evoke sensual comforts (music, flannel) that are perceived and processed by the brain; only with my hat, it's abstracted and externalized into fashionable form so that viewers ponder connections.

It's part of a show currently on at the Femina Potens gallery in San Francisco until January 28.

The other piece is one I saw at the weekend called Neurotopographics and is a collaboration between artist Antoni Malinowski, architect Bettina Vismann and neuroscientist Hugo Spiers.

It takes inspiration from the recent discovery of three types of neurons that seem specialised for spatial awareness and navigation.

Place cells provide a 'you are here' signal; grid cells signal information about distances travelled and head direction cells provide a sort of internal compass.

So far, these have only been discovered in rats, but Spiers and his collaborators have created a film of how they might operate in humans.

In fact, they've created three films which run simultaneously:

The resulting artwork – which will be on show at the Gimpel Fils Gallery from 18–21 January – follows the journey of a person through space, in this case the gallery itself. The actor is filmed from two camera viewpoints: a static wide angle position, which records movement and spatial position, similar to a surveillance camera; and from a dynamic point of view, filmed out of the perspective of the actor’s eyes, recording the subjective impressions of the space and his journey through it. The films will be simultaneously projected onto the gallery walls and combined with a two-dimensional animation displayed on the floor representing assumed brain cell activity patterns.

Rather annoying, the website only works properly in Explorer, but the film from the observational point of view and the firing of the cells can be experienced online.

Link to Femina Potens gallery.
Link to Neurotopographics website.

—Vaughan.

January 21, 2008

The inner body:

NPR's radio show Talk of the Nation has a discussion with Sandra and Matthew Blakeslee, authors of a new book on the neuroscience of the body and movement.

If you're interested in the ideas of embodied cognition that we covered the other day, the discussion touches on many of the major findings in cognitive science that are feeding into this important area.

The book, called The Body Has a Mind of Its Own, has a website which is somewhat sparse on readable excerpts but does have links to some more interviews about the topic.

The host of the NPR programme is a bit taken by the idea of 'body maps' (called sensory or somatotopic maps in the scientific literature), where areas of the body are literally mapped by the brain to represent sensation and movement, and the Blakeslees get asked lots of variations on the question 'how do body maps explain x, y and z'.

Of course, somatotopic maps are only one part of a complex brain system that perceives the outside world and allows us to act within it, but I wonder whether this is a sign that 'body maps' might be the new 'mirror neurons' and become a popular explanation for everything from winning the World Cup to finding a partner.

Either way, Sandra and Matthew Blakeslee do a great job of explaining the science and trying to draw out some of the complexities.

Link to NPR discussion.
Link to The Body Has a Mind of Its Own website.

—Vaughan.

January 17, 2008

Can stress stop the menstrual cycle?:

Inkling has an interesting article on the effect of stress on the menstrual cycle that investigates the received wisdom that stress can prevent periods.

It turns out the scientific studies have found no conclusive answer as they've returned mixed results, but this may be because they don't adequately distinguish between physical stress and psychological stress.

A range of physical health problems are known to halt menstruation. Malnutrition is a common example and this is why women with anorexia often don't have periods.

Of course, physical and psychological stress go hand in hand, but one study that looked at healthy young women under a great deal of psychological stress, but no major physical health problems, found no alteration in the menstrual cycle.

So Ellison examined female juniors at Harvard who were preparing for the MCAT [Medical College Admission Test] and compared their anxiety levels (and ovulation schedules) to women who were not preparing for the MCAT. In order to make sure there were no other factors at play, all the women were otherwise physically healthy, were not using any oral contraceptive pill that would change hormone levels, and all reported normal ovulation...

But despite the significant increase in stress, there was no change in ovulation or periods in either group. No matter how stressed these students were about the upcoming exam, they continued to have a visit from Aunt Flow right on schedule. This was even the case during the final days and weeks leading up to the MCAT exam, when the subjects described intense stress levels that only Harvard pre-meds can sustain. The study was published in the December 2007 issue of the American Journal of Physical Anthropology.

There's more on the effects of stress on menstruation in the article.

Link to Inkling article 'Of Stress and Periods'.

—Vaughan.

January 16, 2008

Mind, body and goal: the embodied cognition revolution:

The Boston Globe just published an excellent article on 'embodied cognition', an area that's recently been getting a lot of attention in cognitive science and which argues that we can't understand psychology without understanding the body and our actions.

The reason it's so potentially revolutionary is that it challenges the idea that psychology can be understood as a purely abstract mental process and suggests that our mind is shaped as much by our body and how we physically interact with the environment as by 'passive' sensory experience.

In other words, the reason we've developed thinking brains is to allow us to act, and so the possibilities, limitations and feedback from actions must shape our psychology - both in the long term as a species (via evolution) and in the short term as individuals (via learning and plasticity).

The body, it appears, can subtly shape people's preferences. A study led by John Cacioppo, director of the Center for Cognitive and Social Neuroscience at the University of Chicago, found that subjects (all non-Chinese speakers) shown a series of Chinese ideographs while either pushing down or pulling up on a table in front of them will say they prefer the ideographs they saw when pulling upward over the ones they saw while pushing downward. Work by Beilock and Holt found that expert typists, when shown pairs of two-letter combinations and told to pick their favorite, tend to pick the pairs that are easier to type - without being able to explain why they did so.

Some of my favourite research in this area is by psychologist Dennis Proffitt who has found a range of bodily effects on perception.

In one particularly striking study, Proffitt and his colleagues found that we perceive distances as shorter when we have a tool in our hand, but only when we intend to use it.

They suggest that we perceive the environment in terms of our intentions and abilities to act within it.

Link to Boston Globe article 'Don't just stand there, think'.
Link to great introduction to embodied cognition.

—Vaughan.

January 15, 2008

Jesuit hypochondria in early modern Naples:

I always assumed Early Science and Medicine was what happened during 9am ward meetings, but it's apparently an academic history journal.

In a recent issue, it has a curious article that discusses a 'plague' of 'hypochondria' (an unfounded fear of serious illness) that apparently swept through the Jesuit community in 17th century Naples.

The first sentence of the abstract is completely priceless.

Poetry or pathology? Jesuit hypochondria in early modern Naples.

Early Science and Medicine, 12 (2), 187-213.

Haskell Y.

In their didactic poems on fishing and chocolate, both published in 1689, two Neapolitan Jesuits digressed to record and lament a devastating 'plague' of 'hypochondria'. The poetic plagues of Niccolò Giannettasio and Tommaso Strozzi have literary precedents in Lucretius, Vergil, and Fracastoro, but it will be argued that they also have a real, contemporary significance. Hypochondria was considered to be a serious (and epidemic) illness in the seventeenth century, with symptoms ranging from depression to delusions. Not only did our Jesuit poets claim to have suffered from it, but so did prominent members of the 'Accademia degl'Investiganti', a scientific society in Naples that was at odds with both the religious and medical establishments.

Link to PubMed entry.

—Vaughan.

January 14, 2008

Mapping emotions onto the city streets:

Christian Nold maps cities. But instead of mapping their physical layout, he maps their emotional geography.

He uses a technique he invented called biomapping where participants walk the area connected to a system that measures galvanic skin response - a measure of the electrical resistance of the skin which is known to give a rating of arousal and stress.

The system is also connected to a GPS device, so the stress response of each person is physically mapped onto the landscape.

His maps describe an area in terms of how stressful it is, and so far, he's mapped Greenwich in London, San Francisco and Stockport.

He's also done a project that maps the sensory experiences of Newham.

I had the pleasure of meeting Christian the other night and one of the best things is is that he's persuaded Ordinance Survey, the UK's mapping agency, to print the maps!

I have a copy of the Greenwich map and so far everyone I've showed it to has been blown away.

You can buy paper copies of the maps, but also view them in full detail online.

Link to Emotion Map.
Link to Christian Nold's website.

—Vaughan.

Higher price makes cheap wine taste better:

A new brain scanning study has supported what we've suspected all along, more expensive wine tastes better partly because we expect it to.

Neuroscientist Hilke Plassman led a brain-scanning study [pdf], shortly to be published in the Proceedings of the National Academy of Sciences, where volunteers were asked to taste and rate five different wines, each individually priced.

What the volunteers didn't know was that there were only three different wines, and two of them were tasted twice. One one occasion it was described as costing $90 a bottle, on another as costing $10 a bottle.

The volunteers rated the 'more expensive' wine as significantly more likeable despite being identical to the 'cheaper' wine.

In addition, the brain scans showed when the volunteers tasted the wine they thought was more expensive, their brains showed increased activity in the medial orbitofrontal cortex (mOFC) and its surrounding area, the rostral anterior cingulate cortex (rACC), both areas of the frontal lobes.

The orbitofrontal cortex is known to be involved in the regulation of emotions and encoding the 'value' of experiences. Unsurprisingly, it has been identified as a key area in studies of gambling.

However, it has also been previously found to correlate with ratings of pleasantness of smells, tastes and even music.

Interestingly, there was no difference in the brain areas directly related to experiencing taste, and the researchers suggest that the belief that the wine is more expensive probably doesn't directly change our sensory experience, but leads us to think that the experience is more 'valuable'.

The results echo behavioural studies which have found that the same wine is rated differently when served in different quality bottles.

pdf of full-text paper.
Link to write-up from The Times.

—Vaughan.

January 11, 2008

Fighting over inner experience:

Salon has an entertaining review of the new book Describing Inner Experience which is sort of a combination of an argument and a self-consciousness showdown between philosopher Eric Schwitzgebel and psychologist Russell Hurlburt.

Schwitzgebel is sceptical that we can accurately describe our inner thoughts and experiences, while Hurlburt feels that we are capable of doing so, when properly directed.

If you think that it's obvious we can describe our inner mental states, start by reading the review and you'll get a flavour of what the problem is.

At the beginning of the book's central section, Hurlburt and Schwitzgebel meet their volunteer. Her pseudonym is Melanie. She is in her 20s, and she has an interest in psychology but no experience in these debates. Hurlburt explains the rules to her: She will simply tell them what was on her mind just before each beep, and they will try to figure out if her reports are accurate.

Hurlburt handles the direct questioning, then turns her over to Schwitzgebel for cross-examination. They have six sessions, each about an hour long. And over the course of these sessions, something unexpected happens, a novelistic twist that is subtle, hilarious and hard to describe. A battle for interpretive credibility emerges, as the doubt Schwitzgebel casts upon Melanie's self-understanding rebounds upon himself.

The preface and first chapter of the book are freely available online if you want to learn more, and the book itself has just been published.

Link to Salon review.
Link to details of book and sample preface and chapter.

—Vaughan.

January 08, 2008

Knock, knock, room service:

NPR has a short piece on a fascinating study where the researchers informed hotel maids that their normal work counted as exercise, which had the effect of making them more physically fit, despite them not seeming to change their activity levels.

Unfortunately, the NPR segment seems to suggest that the study 'challenges the placebo effect', based on the faulty assumption that the placebo effect only alters 'subjective perception'.

In fact, placebos are known to affect outcome in a range of physical illnesses (and even produce placebo 'side-effects - known as the nocebo effect), and they have been shown to directly stimulate the same brain circuit when they are used to replace a drug to treat Parkinson's disease.

Furthermore, the study itself [pdf] claims to demonstrate the placebo effect in a new domain.

Despite this, it's a fascinating study and raises a number of intriguing questions, such as whether the placebo effect is directly affecting body metabolism, or whether the information given to the maids just made them behave differently, and actually do their work in a way to give more health benefits.

Link to NPR piece on the study.
pdf of full-text of study.

—Vaughan.

January 05, 2008

ECT: the blues and the electric avenue:

Electroconvulsive therapy, ECT or electroshock therapy is the most controversial treatment in psychiatry, and it's also the most misunderstood.

It's impossible to discuss ECT without mentioning One Flew Over the Cuckoo's Nest because the book, the play and the film have given us the most culturally salient image of the treatment.

Kesey depicts it as little more than tool of oppression to subjugate Randal P. McMurphy who is only in hospital because, as far as he can figure out, "I, uh, fight and fuck too much".

This negative portrayal is almost standard in the film industry but captures little of the reality of the average ECT treatment, which is usually prescribed for depression of the most severe kind (it is sometimes used for psychosis and catatonia, but much less frequently).

ECT treatment involves passing about 800 milliamps of electricity through the brain. 800 milliamps is a bit more than your average mobile phone battery puts out, but is quite significant as far as the brain is concerned and is enough to cause a seizure.

The current can be applied to both sides of the brain (bilaterally, most common) or one side only (unilaterally, less common), and can take the form of a pulse (most common) or a sine-wave (less common). There is evidence to suggest that different versions have different benefits and side effects, but the choice may depend on national guidelines or clinic preference.

This effect on the brain is essentially the same as an epileptic seizure, but it looks quite different. This is because the patient is given a general anaesthetic, so they are unconscious, and a muscle relaxant, so there is barely any movement.

In terms of physical health risks, ECT is thought to be much safer than most drug treatments and is often prescribed to people in the most fragile state of health (e.g. pregnant women, the elderly) for exactly this reason.

The biggest risk to health is actually the anaesthetic and muscle relaxant drug, which is the main reason a heart and general medical check-up is given before treatment.

ECT is usually given in doses of 6-12 treatments over a similar number of weeks (psychiatrists seem to have a superstition about giving an odd number of treatments for some reason, and so it is usually given in 'pairs' of doses), although can be given as a 'maintenance' treatment, less frequently, over longer periods.

We still don't know how ECT works, although effects on brain plasticity (physical change and adaptation) and neurochemistry are being investigated.

In terms of its effectiveness and impact, the whole business of ECT is a complicated issue, but here's what the current evidence suggests.

At least in the short-term, it is one of the most rapid and effective treatments for severe depression.

It is associated with ongoing memory difficulties, even after the treatment has stopped.

Patients generally view it much less favourably than clinicians, and it is generally viewed negatively by the public and carries significant stigma.

Now here are the caveats: because ECT is typically given to the most severely depressed patients (who likely already have cognitive problems), it is difficult to do ideally balanced, gold standard randomised controlled trials that give a good matched measure of both benefit and side-effects. In fact, these sorts of studies have not been done.

This is why there is disagreement, even with the medical and scientific community, about its effects, both good and bad.

Furthermore, Dr Richard Abrams, one of the leaders in ECT research and author of the standard clinical textbook, has a financial interest in, and reportedly owns, Somatics, one the world's biggest suppliers of ECT machines and equipment. This makes some people suspicious of his promotion of the treatment.

However, Dr Harold Sackheim, probably the other 'big name' in ECT research, has no financial interests in any ECT company and does not receive financial compensation for consultation with the ECT industry.

Importantly, there is considerable individual variation in how people respond to ECT, in terms of their symptoms, post-treatment cognitive impairment, their subjective experience, and their attitudes.

Some people find ECT ineffective and damaging, others feel their life has been saved and their illness properly treated for the first time.

There are many articulate and moving accounts of the treatment on the web. Journalist Liz Spikol found ECT largely unhelpful and suffered debilitating cognitive effects, while surgeon Sherwin Nuland found it was the only thing that helped him recover and return to work.

Perhaps the most controversial topic is involuntary or forced treatment.

The majority of ECT patients volunteer for the treatment (usually on the suggestion of their doctors) and sign a consent form for treatment.

In some countries, where law allows, a minority of patients are treated with ECT against their will, usually if they are deemed to be a danger to themselves or others, and where other treatments have failed.

In a nutshell, it seems to be the most effective treatment for severe depression, seems to impair memory, is disliked and stigmatised, and is difficult to research. Most notably, as a patient, your mileage may vary. Some people have no benefit, some have huge improvement; some have no side-effects, some have ongoing difficulties. Most have some of each.

It's also really hard to have a sensible discussion about ECT because of the emotions it stirs up. Like any treatment that provokes such opposite reactions from both those that have had it, and those that haven't, it's worth learning more with a cool head and an open heart.

I've avoided giving my own opinions on the treatment, which, like the evidence are complex, but I hope you'll learn more, decide for yourself and be able to consider both new scientific evidence and reaction from people you meet who have had, or are considering ECT.

Link to Wikipedia page on ECT.

—Vaughan.

December 30, 2007

When a Rose Is Not Red:

There's an interesting article in January's Journal of Cognitive Neuroscience about a brain injured patient who has a curious form of simultanagnosia - the inability to perceive more than one object at once.

In this case, he also seemed unable to report more than one attribute, like colour or name, at a time, while looking at the object.

Simultanagnosia: When a Rose Is Not Red.

J Cogn Neurosci. 2008, 20 (1), 36-48

Coslett HB, Lie G.

Information regarding object identity ("what") and spatial location ("where/how to") is largely segregated in visual processing. Under most circumstances, however, object identity and location are linked. We report data from a simultanagnosic patient (K.E.) with bilateral posterior parietal infarcts who was unable to "see" more than one object in an array despite relatively preserved object processing and normal preattentive processing. K.E. also demonstrated a finding that has not, to our knowledge, been reported: He was unable to report more than one attribute of a single object. For example, he was unable to name the color of the ink in which words were written despite naming the word correctly. Several experiments demonstrated, however, that perceptual attributes that he was unable to report influenced his performance. We suggest that binding of object identity and location is a limited-capacity operation that is essential for conscious awareness for which the posterior parietal lobe is crucial.

This is particularly interesting because it relates to a key question in understanding consciousness, known as the 'binding problem'.

The brain deals with different parts of perception (for example movement, colour, light-dark differences) in different parts of the brain, yet when we perceive an object, it all seems to be integrated into one conscious experience.

For example, our experience of an object's colour and movement never seem to be 'out of synch'. How this happens is the essence of the binding problem.

This case report is of someone whose brain injury seems to prevent 'binding'.

Looking at what brain injured patients can no longer do and matching this with the damaged areas can give us a clue to how the brain works because "you don't know what you've got 'till it's gone".

Strictly speaking, this is called the transparency assumption in cognitive neuropsychology but I call it the Joni Mitchell principle as the quote is a song lyric of hers (I got this from a student essay I once marked so thank you insightful mystery student!).

In this case, the patient suffered damage to both sides of the back of the parietal lobes because of a stroke ("bilateral posterior parietal infarcts"), suggesting the parietal lobes might be key in binding perceptual elements for consciousness.

Unfortunately, I can't get to the full-text of the paper yet, so I'm not sure what insights the authors themselves have offered. Still, a fascinating case.

Link to PubMed abstract.

—Vaughan.

December 25, 2007

Not just a pretty face:

The Economist has a fascinating article on the link between beauty, intelligence and success. It reviews research showing that beautiful people are actually, on average, slightly more intelligent and it's probably a result of genetics.

The first half of the article looks at the psychological research that has found that beauty, and particularly symmetry, is linked to health and intelligence.

Interestingly, visual beauty is only a clue to intelligence at certain stages in life:

They found that the faces of children and adults of middling years did seem to give away intelligence, while those of teenagers and the elderly did not. That is surprising because face-reading of this sort must surely be important in mate selection, and the teenage years are the time when such selection is likely to be at its most intense—though, conversely, they are also the time when evolution will be working hardest to cover up any deficiencies, and the hormone-driven changes taking place during puberty might provide the material needed to do that.

Nevertheless, the accumulating evidence suggests that physical characteristics do give clues about intelligence, that such clues are picked up by other people, and that these clues are also associated with beauty.

The second half of the article reviews an innovative approach to the effect of beauty by economist Daniel Hamermesh.

He's found a robust link between financial success and beauty (interestingly which differs across cultures), but has also looked at the cost-effectiveness of using cosmetics and clothing to boost attractiveness.

It turns out, it's a poor investment. His research study [pdf] found that the financial boost generate by using clothes and beauty treatments only covers 15% of their cost.

Link to Economist article on beauty and success.
pdf of Hamermesh's paper 'Dress for Success: Does Primping Pay?'.

—Vaughan.

December 18, 2007

Alcohol, the cause and solution to all of life's problems:

As the Christmas season is upon us, what better time to think about alcohol, aptly described by Homer Simpson as the "the cause and solution to all of life's problems".

The British Medical Journal has a wonderful article that tells you everything you wanted to know about alcohol (but were too drunk to ask) in one concise package.

It covers the effect of alcohol on the body and brain, and describes what affects how alcohol is absorbed into the body:

Rate of absorption of alcohol depends on several factors. It is quickest, for example, when alcohol is drunk on an empty stomach and the concentration of alcohol is 20-30%. Thus, sherry, with an alcohol concentration of about 20% increases the levels of alcohol in blood more rapidly than beer (3-8%), while spirits (40%) delay gastric emptying and inhibit absorption. Drinks aerated with carbon dioxide—for example, whisky and soda, and champagne—get into the system quicker. Food, and particularly carbohydrate, retards absorption: blood concentrations may not reach a quarter of those achieved on an empty stomach. The pleasurable effects of alcohol are best achieved with a meal or when alcohol is drunk diluted, in the case of spirits.

It also notes that blood alcohol level is affected by stage of the menstrual cycle in women. Apparently, it is highest premenstrually and at ovulation (evolutionary psychologists, start your engines).

Different effect are compared to the amount of alcohol in the blood stream, so it's a really handy summary.

The BMJ also published a systematic review of hangover cures and preventions later in the year, and found, rather sadly, that:

No compelling evidence exists to suggest that any conventional or complementary intervention is effective for preventing or treating alcohol hangover. The most effective way to avoid the symptoms of alcohol induced hangover is to practise abstinence or moderation.

Bugger.

Link to BMJ article 'ABC of Alcohol'.
Link to BMJ systematic review on hangover cures and preventions.

—Vaughan.

December 12, 2007

What IQ doesn’t tell you about race:

IQ has suddenly become a hot topic again, owing to a certain DNA-discovering Nobel laureate putting his foot in his mouth and the publication of a couple of books on the subject. Malcolm Gladwell has written a great article for the New Yorker that summarises many of the recent arguments and suggests why comparing IQ scores of different races is doomed to failure.

IQ is designed so it always has a mean of 100 and a standard deviation of 15. However, during the past decades people have been scoring better on IQ tests, something known as the Flynn effect, meaning the new versions have been re-adjusted to make sure the mean stays at 100.

This is important, because it means that comparing IQ from the 1950s is not a far comparison to IQs from the 2000s, because they use tests with different standards.

Some of the people who argued that certain races are more intelligent than others have failed to include these changes in their calculations, and, as Gladwell points out, when these are accounted for, many of these differences completely disappear.

The best way to understand why I.Q.s rise, Flynn argues, is to look at one of the most widely used I.Q. tests, the so-called WISC (for Wechsler Intelligence Scale for Children)...

For instance, Flynn shows what happens when we recognize that I.Q. is not a freestanding number but a value attached to a specific time and a specific test. When an I.Q. test is created, he reminds us, it is calibrated or “normed” so that the test-takers in the fiftieth percentile—those exactly at the median—are assigned a score of 100. But since I.Q.s are always rising, the only way to keep that hundred-point benchmark is periodically to make the tests more difficult—to “renorm” them. The original WISC was normed in the late nineteen-forties. It was then renormed in the early nineteen-seventies, as the WISC-R; renormed a third time in the late eighties, as the WISC III; and renormed again a few years ago, as the WISC IV—with each version just a little harder than its predecessor. The notion that anyone “has” an I.Q. of a certain number, then, is meaningless unless you know which WISC he took, and when he took it, since there’s a substantial difference between getting a 130 on the WISC IV and getting a 130 on the much easier WISC.

Link to Malcolm Gladwell article in the New Yorker.

—Vaughan.

December 06, 2007

Almost perfect:

The New York Times has a short article on mental health and perfectionism, the tendency to measure success and self-worth by the completion of often unrealistic goals.

Over the last two decades this concept is being increasingly seen as a core component in some types of types of depression, anxiety and obsessive-compulsive and eating disorders.

A recent study identified several key features of perfectionism as, primarily, excessive concern over making mistakes, with other influences including high personal standards, the perception of high expectations and criticism from parents, doubting of the quality of your own actions, and a preference for order and organisation.

One of the key papers [pdf] in the field that really cemented the idea of perfectionism as an important psychological idea, suggested perfectionism could be focused inward (stringently evaluating and censuring your own behaviour), other-oriented perfectionism (having unrealistic standards for other people) and socially prescribed perfectionism (living up to unrealistic standards which the person perceives others are setting).

For people who already have negative ideas about themselves, perfectionism is thought to work like a constant test. If you can prove to yourself you can pass the test, you feel like a good person.

However, if the standards are unrealistic, you're always going to fail, and ironically, concern and anxiety about achieving these high standards can actually lead to putting things off, or doing the tasks worse.

This can lead to a vicious circle where people feel their emotional well-being is dependent on them reaching impossible goals, but trying to reach the goal makes them feel even worse.

One of the difficult things in psychological treatment, is often trying to persuade people that performing worse is actually a good thing. 'Good enough' rather than 'perfect'.

Link to NYT article on perfectionism.
pdf of key paper 'Perfectionism in the Self and Social Contexts'.

—Vaughan.

November 15, 2007

Does stress turn your hair grey?:

Scientific American has a short article which examines whether there's any truth to the common theory that stress makes your hair go grey. It's turns out there's some circumstantial evidence that stress may have an effect, but no definite causal link has been found.

Apparently, the gradual loss of melanocyte stem cells, ones that are key for hair colouring, lead to the loss of pigment.

Does stress accelerate this demise of the melanocyte population? "It is not so simple," Fisher says, noting that the process of graying is a multivariable equation. Stress hormones may impact the survival and / or activity of melanocytes, but no clear link has been found between stress and gray hair. Suspicions — and hypotheses — abound, however.

"Graying could be a result of chronic free radical damage," says Ralf Paus, professor of dermatology at the University Hospital Schleswig-Holstein in Lübeck, Germany. Stress hormones produced either systemically or locally (by cells in the follicle) could produce inflammation that drives the production of free radicals — unstable molecules that damage cells — and "it is possible that these free radicals could influence melanin production or induce bleaching of melanin," Paus says.

"There is evidence that local expression of stress hormones mediate the signals instructing melanocytes to deliver melanin to keratinocytes," notes Jennifer Lin, a dermatologist who conducts molecular biology research at the Dana-Farber / Harvard Cancer Center in Boston. "Conceivably, if that signal is disrupted, melanin will not deliver pigment to your hair."

And general practice physicians have observed accelerated graying among patients under stress, says Tyler Cymet, head of family medicine at Sinai Hospital in Baltimore, who conducted a small retrospective study on hair graying among patients at Sinai. "We've seen that people who are stressed two to three years report that they turn gray sooner," he says.

Link to SciAm article 'Fact or Fiction?: Stress Causes Gray Hair' (via 3Q).

—Vaughan.

November 14, 2007

Seeing red can really affect performance:

Cognitive Daily discusses the findings of two interesting studies that suggest that simply seeing the colour red makes us perform worse on tests.

The articles discuss a couple of elegant studies by a research team, led by psychologist Andrew Elliot, which confirmed that seeing red makes us tend to do worse on tests. They then set about trying to understand why.

In a second study, students were given test booklets with the title in one of several possible colours. Interestingly, those who had booklets with red titles tended to choose easier questions, which led to a direct test of a neuropsychological idea about brain symmetry and avoidance:

Students who saw the red test cover chose significantly more easy test questions than either those who saw green or gray test covers. There was no significant difference between the students who saw green and gray.

So it seems that the color red in this context may cause people to avoid challenging or difficult situations. In their final experiment, the researchers took advantage of a robust experimental finding about avoidance. For more than two decades, nearly a hundred studies have found a characteristic brain activity associated with avoidance -- asymmetrical activity in the right frontal cortex. This is easily measured using non-invasive EEG equipment.

The research team used exactly this technique and found that relatively greater right hemisphere was found for red material, but not other colours, suggesting red triggers part of the avoidance system.

As Cognitive Daily note, we can't tell from these experiments whether the red and avoidance link is with us from birth, or whether we've just learnt it through cultural exposure.

It's a really elegant couple of studies though, and as always, they're wonderfully explained by the CogDaily team.

Link to 'Does the color red really impair performance on tests?'.
Link to 'Why does seeing red make test-takers choke?'

—Vaughan.

November 13, 2007

The absinthe minded green fairy:

The New York Times has a brief but wonderfully illustrated article on the cultural history of absinthe, the highly alcoholic spirit that was adopted by numerous famous artists.

Wikipedia also has a fantastic article on absinthe which looks at the history of its creation, popularity, prohibition and revival.

It also exposes the myth that wormwood, a key flavouring ingredient, causes hallucinations. A scientific article looked at the evidence for this and found that the effects of the drink are almost entirely due to its alcohol content.

While thujone, an active ingredient in wormwood, can causes seizures in high enough quantities, there isn't enough in absinthe to have a significant effect.

However, erroneous concerns about the drink leading to dangerous forms of 'madness' led it to be banned in most European countries in the early 1900s, giving it an instant notoriety and cultural impact that far goes beyond its pharmacological influence.

Link to NYT on 'Absinthe Returns in a Glass Half Full of Mystique...'
Link to Wikipedia article on absinthe.
Link to scientific article 'Absinthism: a fictitious 19th century syndrome...'

—Vaughan.

Music in dreams:

From a footnote on p282 of Oliver Sacks Musicophilia:

There have been very few systematic studies of music in dreams, though one such [pdf], by Valeria Uga and her colleagues at the University of Florence in 2006, compared the dream logs of thirty-five professional musicians and thirty non-musicians. The researchers concluded that "musicians dreams of music more than twice as much as non-musicians [and] musical dream frequency is related to the age of commencement of musical instruction, but not to the daily load of musical activity. Nearly half of all recalled music was non-standard, suggesting that original music can be created in dreams." While there have been many anecdotal stories of composers creating original compositions in dreams, this is the first study to lend support to the idea.

The finding has an interesting parallel with findings on the 'age-of-acquisition effect' in language research.

It was known for years that things like the ability to name objects or remember words was influenced by the how common the word is, and how 'concrete' it is. For example, concrete words like tree, apple and house tend to be more robust than abstract words like hope, love or like.

Largely due to the work Andy Ellis it's been found that many of these effects are actually a function of at what age the word was first learnt, with earlier words being more robust in terms of being more easily processed or accessed during cognitive processing.

The Uga study hints that a similar process may be at work with music.

Link to PubMed entry for study on music and dreams.
pdf of full-text of music and dreams study.
Link to Google Scholar search for age-of-acquisition effect.

—Vaughan.

November 12, 2007

Hypnosis as a surgical tool:

The editorial of the Journal of the National Cancer Institute discusses a recent study that found that hypnosis can be successfully used in breast cancer surgery to reduce pain, nausea, painkiller use, tiredness and emotional impact of the surgical procedure.

The study was a randomized controlled trial of patients who were undergoing breast surgery either to treat a cancer or to test a lump to see if it was cancerous.

Patients were randomly assigned to either a brief 15-minute hypnosis condition, or to another where the patient discussed their concerns with an empathic psychologist (to make sure the effects weren't just due to having someone their to 'calm their nerves').

The study found that patients given hypnosis needed less painkilling medication, were less nauseous, less emotionally upset, and experienced less pain intensity than the patients in the 'empathic listening' condition.

The editorial notes that the results suggest hypnosis is a powerful tool for helping patients, discusses why it isn't being used more widely, and what we know about how it affects the brain:

Thus, the study in this issue contributes to an impressive body of research using randomized prospective methodology in sizeable patient populations to demonstrate that adjunctive hypnosis substantially reduces pain and anxiety during surgical procedures while decreasing medication use, procedure time, and cost. If a drug were to do that, everyone would by now be using it.

So why don't they? For one thing, there is no mediating industry to sell the product—dangling watches are out of fashion for hypnotic inductions. Plus, there is still lingering suspicion that hypnosis reeks of stage show trickery. After all, the magic wand originated with Mesmer's use of a magnetic stick to presumably alter magnetic fields in patients' bodies. Yet hypnosis is the oldest Western form of psychotherapy. Hypnosis is a state of highly focused attention, with a constriction in peripheral awareness and a heightened responsiveness to social cues. It is most similar to the everyday state of becoming so absorbed in a good movie or a novel that one enters the imagined world and suspends awareness of the usual one, a condition playwrights refer to as the "suspension of disbelief." This state can exert powerful influence on mind and body.

Altering perception using hypnosis results in brain changes that literally reduce pain perception [rather than merely altering the response to pain]. Indeed, simply changing the wording of the hypnotic instruction from "you will feel cool, tingling numbness more than pain" to "the pain will not bother you" alters the brain location of the analgesia from the somatosensory cortex to the anterior cingulate gyrus. Hypnotic alteration of color perception results in bidirectional changes in blood flow in the portions of the visual cortex that process color vision—blood flow in this region increases when color is imagined rather than seen and decreases when color is hypnotically drained from a colorful stimulus. Thus, there is good neurophysiologic reason to believe that hypnosis is potentially a powerful tool to alter perception of pain and associated anxiety.

If you're interested in volunteering for research into the neuropsychology of hypnosis in London (which doesn't involve anything painful!), we're still recruiting participants for sessions at 2pm on Saturday 17th and 24th November.

There's more information at our study web page.

Link to Journal of the National Cancer Institute editorial on hypnosis.
Link to abstract of RCT study.
Link to information on our neuropsychology of hypnosis study.

—Vaughan.

November 10, 2007

Meditation for the nation:

ABC Radio National's All in the Mind just had a programme looking at both the neuroscience of meditation and its increasing use in evidence-based mental health treatments.

Key aspects of meditation are increasingly become adopted into well-researched mainstream cognitive therapies.

Essentially, it's Buddhist mindfulness meditation, repackaged to make it sound more palatable to a wider audience, and often included alongside more traditional approaches.

The two big players in the psychological treatment field at the moment are Mindfulness-based CBT and Acceptance and Commitment Therapy.

Mindfulness approaches seem particularly useful for people with chronic or relapsing symptoms, such as severe relapsing depression, rather than for first-episode or acute conditions.

For example, a key study published in 2000 found that mindfulness-based CBT had a beneficial effect on people who had three or more relapse of depression, but not people who had experienced two relapses or less.

The idea is quite different from cognitive approaches, where clients are encouraged to identify, evaluate and retrain their problematic thoughts and behaviours.

Mindfulness instead encourages people to be fully aware of these troublesome thoughts or sensations, but not to engage with them.

In other words, clients are encouraged to develop a degree of separation from their thoughts and emotions, so they can experience them, but not feel that they are fully controlled by them.

Some research has suggested that this is because mindfulness (and indeed other approaches) improve our ability to monitor, evaluate and engage with our own thoughts - so-called metacognitive ability.

Link to AITM on 'Dr Mindfulness: science and the meditation boom'.

—Vaughan.

November 09, 2007

Dangerous minds:

Malcolm Gladwell has written an excellent article for The New Yorker on the problems with the FBI's methods of profiling serial killers and other serious offenders.

The Behavioral Analysis Unit (formerly the Behavioural Science Unit) is the FBI's psychology unit that aims to research and develop methods of understanding criminal behaviour, police tactics, negotiation, and crime scene analysis.

It is a huge enterprise that exports its expertise around the world. Foreign police forces can often call on their expertise, for free, to help solve domestic cases.

However, in many ways the BAU is a world onto itself. It develops its own techniques that can often be quite distinct from those of non-FBI forensic psychologists. For example, many of its criminal and crime science analysis methods rely heavily on Freudian-style symbolic interpretations.

For example, the FBI classifies serial killers into 'organized' and 'disorganized' types.

Organized serial killers supposedly use logic and planning to commit crimes that fulfil their fantasies. The victim carefully selected, efforts are made to maintain control throughout the crime and the scene is cleaned up afterwards.

In contrast, disorganized serial killers supposedly choose their victims almost randomly and attack in a haphazard way, taking opportunity as it occurs. The crime scene is apparently chaotic and because the 'disorganized killer' has no interest in the person themselves, they may, as Gladwell recounts, "takes steps to obliterate their personalities by quickly knocking them unconscious or covering their faces or otherwise disfiguring them."

Perhaps the thing that raises the most eyebrows is that it publishes and reviews many of its theories in its own in-house journals, meaning they get little outside academic scrutiny.

Gladwell takes a look at some of these ideas in more detail and notes that they haven't faired well to some of the independent academic assessments they've been tested with:

Not long ago, a group of psychologists at the University of Liverpool decided to test the F.B.I.'s assumptions [pdf]. First, they made a list of crime-scene characteristics generally considered to show organization: perhaps the victim was alive during the sex acts, or the body was posed in a certain way, or the murder weapon was missing, or the body was concealed, or torture and restraints were involved. Then they made a list of characteristics showing disorganization: perhaps the victim was beaten, the body was left in an isolated spot, the victim's belongings were scattered, or the murder weapon was improvised.

If the F.B.I. was right, they reasoned, the crime-scene details on each of those two lists should "co-occur" — that is, if you see one or more organized traits in a crime, there should be a reasonably high probability of seeing other organized traits. When they looked at a sample of a hundred serial crimes, however, they couldn’t find any support for the F.B.I.'s distinction. Crimes don't fall into one camp or the other. It turns out that they're almost always a mixture of a few key organized traits and a random array of disorganized traits. Laurence Alison, one of the leaders of the Liverpool group and the author of "The Forensic Psychologist’s Casebook," told me, "The whole business is a lot more complicated than the F.B.I. imagines."

The whole article is a fascinating insight into the world of FBI profiling and notes that the methods may rely as much on cognitive distortions for their impact, as on hard evidence.

UPDATE: The forensic psychologists over at the excellent CrimePsychBlog have some commentary on the Gladwell piece, noting, among other things that Gladwell bases his criticisms on methods of profiling pioneers whose time has long since passed. A scientific approach is apparently now the mainstay of profiling practice and (they hope) that also includes the FBI.

Link to New Yorker article 'Dangerous Minds' (via 3Q).

—Vaughan.

November 08, 2007

Alcohol abuse in the New Testament:

I just found this abstract of a 1987 article from the journal Alcohol and Alcoholism that reviewed attitudes to alcohol in the Bible, and found that boozing was looked on considerably more favourably in the Old Testament than the New.

Alcohol abuse in the New Testament.

Seller SC.

Alcohol and Alcoholism. 1987;22(1):83-90.

The New Testament is similar to the Old Testament in terms of some fundamental attitudes towards alcohol. St Paul, for example, in the spirit of the Old Testament, unequivocally condemns drunkenness but recommends the consumption of wine in moderate amounts. Nevertheless, there are significant differences in emphasis between the two documents. Wine is referred to as God's gift in six of the books from the Old Testament, and no such description is offered in the New Testament. Total abstention seems acceptable only under exceptional circumstances in the Old Testament, while it is implicitly extolled through the exemplary role of John the Baptist in the New Testament. Finally, penalties for drunkards, including loss of salvation, are proportionally more frequent and comprehensive in the New Testament.

Link to PubMed entry for article.

—Vaughan.

November 01, 2007

Psychosis in David Lynch's Inland Empire:

The Psychologist has just made an article available that looks at the parallels between the most recent David Lynch film, Inland Empire, and what we know of the psychology of psychosis.

The article looks at some of the proposed pathologies of psychosis, drawn from cognitive science, and suggests how these are represented in Lynch's latest movie.

Paranoia comes with an inherent sense of personal threat and concomitant fear. Inland Empire’s dark and chilling world is produced in part by David Lynch’s use of story. While fear is generated with genuinely unsettling imagery and dark shadowy lighting, it also comes from the carefully managed attrition of any recognisable storyline. The audience, who have been led through the early stages of the plot with some of the conventional devices of storytelling (coherent dialogue, linear chronology) are suddenly thrown into a world of unfamiliar film cuts, unexplained locations and wordless acting. We are forced to jump to our own conclusions and build what narrative we will from scant concrete evidence as to events. Our sense of sense itself forces us to put something together and, given the presence of ominous emotions and apparent malice, what we put together is a paranoid and terrifying vision of the intentions of the characters in the film and even the world we inhabit.

Lynch's hallucinatory style certainly suggests altered realities and this is not the first time that it has been linked with mind-being reality distortion, as countless interpretations of Mulholland Drive testify.

Link to article 'David Lynch and psychosis'.

—Vaughan.

October 29, 2007

The deadly South American arrow poison:

I've just found a fantastic article on the history of curare, the powerful Amazonian arrow poison that causes paralysis and death. It's from a 2005 edition of the Journal of the Royal College of Physicians Edinburgh and is available online as a pdf.

The article tells the story of how the New World poison came to be known to the West, and how explorers, researchers and 'gentleman scientists' attempted to work out how it had its deadly effect.

Curare can be extracted from several plants but the active ingredient is d-tubocurarine.

It has its effect by blocking the effect of the neurotransmitter acetylcholine at the neuromuscular junction. In other words, it blocks the chemical signals that allow nerve signals to activate the muscle.

You may be interested to know that Botox works in an almost identical fashion. It is used in in very small doses in plastic surgery to supposedly 'smooth' wrinkles.

Actually, the main 'smoothing' effect is due to the fact that the underlying muscles are paralysed and so cannot move to cause creases in the skin.

In larger doses it is also very dangerous. The name is a clue - Botox is short for 'botulinum toxin'.

The article on curare also has some fascinating asides about the myths associated with the compound, and some curious historical incidents associated with it - such as its role in a plot to assassinate the British Prime Minister during World War One.

pdf of article 'Curare: the South American arrow poison'.

—Vaughan.

Faces, genetics and addiction:

BBC Radio 4's science programme Material World just had an interesting edition on the links between face structure, psychological attributes and genetics, as well as a discussion on the science of addiction.

It is well known that certain genetic disorders that affect brain development can also lead to differences in facial structure (the most well-known example being Down Syndrome) owing to the fact that the brain and face develop from closely related groups of cells during embryogenesis.

One interesting example mentioned by medical geneticist Dian Donnai is the link between having a single incisor ('front tooth) and possible problems with brain development.

It's now being found that differences in the face, even in people without genetic disorders, reflect aspects of growth and development that can be linked to psychological attributes (or just as interestingly, are reliably linked to perceived psychological traits).

Psychologist Anthony Little is one of the guests on the programme and, with a number of colleagues, has done some fascinating work in this area (often using morphed or averaged faces like the one on the left) with many of the research articles available online.

The second part of the programme discusses the science of addiction in terms of both its psychology and neurobiology, but also in terms of its place in our culture as a concept that is applied to patterns of excessive behaviour.

Both are engaging discussions and are well-worth a listen.

Link to Material World with permanent audio archive.
realaudio of programme.

—Vaughan.

October 27, 2007

My brain made me do it:

Gerontologist and all-round skeptic Raymond Tallis has written an article for The Times where he laments the rise of 'neurolaw' where brain scan evidence is used in court in an attempt to show that the accused was not responsible for their actions.

Tallis cites the example of the trial of Bobby Joe Long where his lawyers tried to argue (unsuccessfully as it turned out) that he wasn't responsible for his crimes because brain scan evidence showed that he had an overactive amygdala (supposedly suggesting increased aggression) and underactive frontal lobes (supposedly suggesting reduced ability to inhibit aggression).

This, Tallis argues, is hardly evidence for diminished responsibility because it assumes that our brain is some sort of separate 'alien force' that is somehow not 'us', when we generally think of the brain as being synonymous with the self.

However, he goes on to cite the example of an epileptic seizure and argues that this is an example where we definitely can't say the person is responsible for twitching or losing consciousness.

Tallis aims to make a clear cut distinction between these different sorts of action and how we attribute responsibility for them, but he is perhaps relying on the extremes when reality can be full of grey areas.

Each of us has a propensity or threshold for violence, so some people will have aggressive urges more easily than others.

One way of looking at the question is 'how responsible is the person for their actions', but another is 'what strength of urge do we think it is reasonable for a person to inhibit'.

Life experience, genetic factors, brain injury or any forms of neurological disturbance may make urges stronger or reduce our ability to inhibit them.

Some epileptic seizures may be 'irresistible' in this way of thinking (although interestingly, some seizures may cause thoughts or urges that are resistible to varying degrees), whereas other patterns of brain activity will produce desires or intentions that can be more easily suppressed.

A serial killer may genuinely have reduced ability to inhibit violence urges, but at what point do we say that the effort they would have to make to stop them reacting violently is beyond what is considered reasonable or possible.

Link to Times article 'Why blame me? It was all my brain's fault'.

—Vaughan.

October 20, 2007

To the bunkers! No really, to the bunkers:

In another sign the robot revolution is coming, a robot cannon used by the South African military malfunctioned and tragically killed nine and wounded fourteen after firing uncontrollably.

Mechanised self-targeting machine guns with artificial intelligence systems to distinguish between targets (e.g. humans) and non-targets (e.g. trees) are becomingly increasingly common.

Last year Samsung announced that it had developed a machine gun toting robot sentry that can identify and shoot a target up to two miles away.

The system uses twin optical and infrared sensors to identify targets from 2.5 miles in daylight and around half that distance at night. It has a microphone and speakers so that passwords can be exchanged with human troops.

If the password is not accepted the robot can either sound an alarm or fire at the target using rubber bullets or a swivel-mounted K-3 machine gun.

South Korea's northern border is the most heavily militarised zone in the world, and the southern government has poured millions of dollars into automated military technology.

...

The Intelligent Surveillance and Guard Robot was jointly developed with a South Korean university, and is designed to replace some of the troops guarding the border with North Korea.

North Korea?!? When World War Three is over, someone is going to get a Darwin Award for that decision.

Where's Asimov when you need him?

Link to 'Robot Cannon Kills 9, Wounds 14' from Wired (via BB).
Link to new story on Samsung robot sentry.
Link to Samsung page with specs of their robot sentry.

—Vaughan.

September 17, 2007

Lucid dreaming in art and science:

The New York Times has a short article on the recent upsurge of interest in both the arts and sciences on lucid dreaming - a form of reflective self-awareness in which you realise you're dreaming when it occurs.

You can apparently train yourself to increase your chances of having a lucid dream, and proponents say that the self-awareness allows you to change your 'dream reality' at will.

Unfortunately, it's jolly hard to study scientifically, because its rare, unpredictable and you can't signal when it occurs.

This means its hard even to make simple correlations between lucid dreaming and measures of brain activity.

Although